> In human infections of highly pathogenic coronaviruses SARS-CoV and MERS-CoV, the most vulnerable populations are patients over the age of 65 and patients with comorbidities, and design of efficacious vaccines for patients in these groups is difficult. Vaccine formulations that have been developed against SARS-CoV not only fail to protect animal models of aged populations, but also result in immunopathology in younger populations, where SARS disease is enhanced in vaccinated groups that are subsequently challenged with SARSCoV
That's from USAMRIID research into broad-spectrum coronavirus antiviral drugs released in March 2019 [0], relevant citations in the paper.
They also mention the possibility of using a "modular vaccine platform", which would be RNA vaccines, but they only considered their use for emergency coverage and also point out how vaccines alone are unlikely to eradicate it, as long as the virus continues to circulate in potential animal reservoirs.
While earlier in the paper it's pointed out;
> Gammacoronaviruses and deltacoronaviruses have no known viruses that infect humans, but contain important agricultural pathogens of livestock.
Which is also an angle that seems weirdly lacking from the public debate [1]
That's from USAMRIID research into broad-spectrum coronavirus antiviral drugs released in March 2019 [0], relevant citations in the paper.
They also mention the possibility of using a "modular vaccine platform", which would be RNA vaccines, but they only considered their use for emergency coverage and also point out how vaccines alone are unlikely to eradicate it, as long as the virus continues to circulate in potential animal reservoirs.
While earlier in the paper it's pointed out;
> Gammacoronaviruses and deltacoronaviruses have no known viruses that infect humans, but contain important agricultural pathogens of livestock.
Which is also an angle that seems weirdly lacking from the public debate [1]
[0] https://sci-hub.ru/10.1080/17460441.2019.1581171
[1] https://onlinelibrary.wiley.com/doi/full/10.1111/xen.12591