Yes, Esketamine (what they're calling S-ketamine) can be a good one. Just be careful if there's any history of psychosis.

It nearly got me stabbed and had to be discontinued. It really can work on depression, though, in a way the other drugs just don't.

Makes me wonder how much the others are doing, honestly, though missing a dose causes misery. I truly wonder sometimes what just slowly getting off them all would do to her.