It's interesting that they chose to design a fully enclosed cargo airplane. There was a proposal a while back for a flying "flatbed truck" which could carry bulky cargo on an open platform behind a pressurized cockpit. It seems like a similar design might work here. Fuel consumption would be high due to the extra drag but cargo operations would be easier.

https://youtu.be/d-DM2eJIS9k?si=nN7gnJdyJ141UVpP